THE EFFECT OF SELENIUM ON MORPHOFUNCTIONAL CHANGES AND THE CHEMICAL COMPOSITION OF THE LIVER OF WISTAR RATS
Keywords:
Selenium, rats, liver, trace elements, hypoxia, heavy metals, metabolismAbstract
The article analyzes the functional transformations of the liver and its chemical
composition as a result of increased intake of selenium in the form of dietary supplements. This will
expand the understanding of the ecological and toxicological characteristics of the action of the
trace element selenium. The results of a subacute experiment conducted on male rats of the Wistar
line are described. The animals are divided into groups of 15 rats each. The first group is control.
The experimental group «Se» was orally administered sodium selenite daily with a dose of selenium
1 mg/kg. Selenium, received in the form of sodium selenite at a dose of 1 mg / kg, contributes to a
change in biochemical parameters characterizing liver function, as well as the elemental composition
of the organ.
References
Миних В.Б. Базовые аспекты метаболизма селена и биосинтеза селенопротеинов в организме человека // Успехи биологической химии. 2022. –Т. 62. – С. 369-390
Schiavon М., Nardi S., Francesca dalla Vecchia & Andrea Ertani Selenium biofortification in
the 21st century: status and challenges for healthy human nutrition // Plant Soil. 2020. – Jul 16. – C.1-
Голубкина Н. А., Папазян Т.Т. Селен в питании: растения, животные, человек. М.: Изд-во
Печатный город; 2006, – 254 с.
Hossain A., Skalicky M., Brestic M. et al.. Selenium Biofortification: Roles, Mechanisms,
Responses and Prospects // Molecules. 2021. – 26(4). – 881 р.
Голубкина Н.А. Экологические аспекты обогащения продуктов питания селеном // Экологические системы и приборы. 2004. – №7. – С. 32-35.
Егорова Е.А. и др. Изучение биодоступности различных пищевых форм микроэлемента
селена в эксперименте // Вопросы питания. 2006. –Т. 75, №3. – С. 45-49.
Синдирева А.В. Критерии и параметры действия микроэлементов в системе «почва – растение – животное»: дис. … д-ра биол. наук . Омск, 2012. – 455 с.
Combs G.F.J. Selenium in nutrition. Encyclopedia of human biology. 1997; 7: –Р. 743-754.
Sindireva A.V., Zayko O.A. , Astashov V.V. Ecological and toxicological evaluation of the impact
of selenium contained in feed on morphological and functional changes in the bone tissue of animals.
Journal Archiv Euromedica. 2018. – 2. – С.12-14.